Cardiolipin Antibodies (IgG, IgM, and IgA) is to investigate inappropriate blood clot formation, to help determine the cause of recurrent miscarriage, or as part of an evaluation for antiphospholipid syndrome or sometimes other autoimmune diseases with the help of blood sample.
Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly systemic lupus erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren’s syndrome.
Cardiolipin Antibody (IgA)
?11 APL Negative
12-20 APL Indeterminate
21-80 APL Low to medium positive
>80 APL High positive
Cardiolipin Antibody (IgG)
?14 GPL Negative
15-20 GPL Indeterminate
21-80 GPL Low to medium positive
>80 GPL High positive
Cardiolipin Antibody (IgM)
?12 MPL Negative
13-20 MPL Indeterminate
21-80 MPL Low to medium positive
>80 MPL High positive
